Investigations on the Antimalarial Properties of Cleistopholis patens (Annonaceae) Leaf Methanol Extract and Its Partitioned Fractions in Mice

Aim: The methanol extract and partitioned fractions of Cleistopholis patens leaf were evaluated for antiplasmodial activities with a view to establishing its antimalarial potential identifying the most active fraction.
 Methods: was collected, authenticated, air-dried powdered. extract, prepared by maceration in tested (0-800 mg/kg) against P. berghei mice using Peter’s four-day test. Normal saline Chloroquine (10 negative positive control respectively. Percentage parasitemia, percentage chemosuppression, effective doses, survival times survivors parameters used assessment. thereafter suspended water successively into n-hexane, dichloromethane ethyl acetate resulting aqueous phase similarly at doses 10-80 mg/kg.
 Results: which comparable (P=.06) activity chloroquine gave 1.05±0.09 77.45±4.39 chemosuppression 40 mg/kg an ED50 ED90 255.83±3.60 471.35±15.05 mg/kg. n-hexane fraction elicited 82%, 0.87 parasitaemia 80 mg/kg, moderately high survivor relatively low 28.87±5.29 56.30±8.44 Conclusion: C. is compounds likely be concentrated fraction.